Use Case

Real-world evidence

Continuous biomarkers from CGM, wearables, and patient-reported outcomes. Track drug and device effectiveness in real-world settings. Supplement RCTs with longitudinal observational data. Generate evidence for Asia Pacific regulatory submissions and health technology assessments.

Post-market Study
Active
1,247
Patients
180
Days tracked
8.9M
CGM readings
Primary outcomes
Mean HbA1c reduction
-0.8%
Time in range improvement
+12.3%

Beyond traditional RCTs

Randomized trials provide efficacy data in controlled settings. But Asia Pacific regulators increasingly want real-world effectiveness. How does the drug or device perform when patients skip doses, face comorbidities, or live in diverse real-world environments?

RCTs show efficacy, not real-world effectiveness
Limited diversity in trial populations
Short follow-up periods miss long-term effects
Expensive to run large post-market studies
Traditional RCT
Duration
6-12 months
Participants
200-400
Cost
$$$$$
RWE with HealthGen
Duration
Continuous
Participants
1000+
Cost
$$
6-month longitudinal tracking
Baseline
HbA1c
8.2%
Time in range
52%
Month 3
HbA1c
7.6%
Time in range
61%
Month 6
HbA1c
7.4%
Time in range
64%
Continuous data density
288 CGM readings/day × 180 days = 51,840 datapoints/patient

Continuous digital biomarkers

CGM captures glucose every 5 minutes. Wearables track steps, sleep, heart rate continuously. Supplement quarterly HbA1c with daily time-in-range. Capture real-world adherence, not just trial protocol compliance.

288 glucose readings per day
vs quarterly HbA1c in trials
Real-world adherence tracking
Device data shows actual wear time
Longitudinal trend analysis
6+ months of continuous monitoring
Subgroup discovery
Find which patients respond best

Evidence for Asia Pacific regulators

HSA Singapore, PMDA Japan, TGA Australia, and NMPA China increasingly accept RWE for post-market surveillance and regulatory decision-making. Export analysis-ready datasets with full audit trails. Meet stringent adverse event reporting timelines and registry requirements.

HSA Singapore
Post-market surveillance and adverse event reporting
PMDA Japan
Registry data for post-marketing studies
TGA Australia / NMPA China
Real-world effectiveness and safety data
RWE Evidence Package
Participant-level dataset
Parquet, 2.3 GB
Audit trail & metadata
JSON, 12 MB
Protocol documentation
PDF
Statistical analysis plan
Markdown
Submission-ready exports available

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See how HealthGen can help you ship faster, scale further, and get to insights without rebuilding the stack.